December 22, 2008

2008 Research Highlights — Clinical Breakthroughs

Prevention, Diagnosis and Treatment of Human Disease

¿ìÈý¹ÙÍø has nearly 6,000 ¿ìÈý¹ÙÍø staff scientists and supports more than 325,000 researchers with competitive grants to all 50 states, the territories and more than 90 countries around the world. Here's just a small sampling of the accomplishments made by ¿ìÈý¹ÙÍø-supported scientists in 2008.

Dietary Supplements Fail to Prevent Prostate Cancer

Two large ¿ìÈý¹ÙÍø-funded clinical trials found that taking vitamin E, vitamin C or selenium does not reduce the risk of prostate cancer or other cancers in older men, as some previous studies had suggested. The results highlight the fact that dietary supplements can sometimes seem beneficial in small observational studies, but large, carefully controlled trials are needed to test whether they really live up to their hoped-for benefits.

Intensive Blood Sugar Control in Type 2 Diabetes

People with type 2 diabetes need to keep their blood sugar from getting too high. But a large ¿ìÈý¹ÙÍø-funded clinical trial found that tighter control isn't always better. A therapeutic strategy designed to aggressively control blood sugar in adults with diabetes who are also at high risk for cardiovascular disease not only failed to reduce the risk of major cardiovascular events; it actually raised patients' risk of death.

Smokers Band Together and Quit Together

Spouses, friends, siblings and co-workers usually decide to light up or stub out their cigarettes for good around the same time, an ¿ìÈý¹ÙÍø-funded study found. Married couples seemed to exert the greatest influence on each other. When one spouse quit smoking, the other’s likelihood of smoking dropped by nearly 70%. A better understanding of how social ties affect smoking behavior may lead to more effective ways to prevent or reduce smoking.

Treatment Lowers Preterm Infants’ Risk for Cerebral Palsy

Preterm infants born to mothers receiving intravenous magnesium sulfate-a common treatment to delay labor-are less likely to develop cerebral palsy than those whose mothers don't receive it, according to ¿ìÈý¹ÙÍø-supported research. The study, involving more than 2,200 pregnant women, is the largest, most comprehensive effort to date to examine the link between the often-used drug and cerebral palsy.

Laser Treatment Best for Diabetic Macular Edema

Traditional laser therapy proved more effective than newer steroid injections for treating people with diabetes who have abnormal swelling in the eye, a condition called diabetic macular edema. About 700 patients were studied in the ¿ìÈý¹ÙÍø-funded clinical trial, which showed that laser therapy protected against vision loss and had far fewer side effects than the corticosteroid treatments.

Wide Waists Boost Mortality Risk

Even if your weight is in the normal range, your risk of death increases if your waist is wide, according to research by ¿ìÈý¹ÙÍø scientists. The investigators studied nearly a quarter-million people over age 50. Those with the largest waists had about a 25% higher mortality risk than those with a normal-sized waist. Normal-weight people with large waists had a 20% higher risk of death than those with both a normal weight and waist size.

Children’s Physical Activity Drops from Age 9 to 15

Physical activity levels sharply declined in a large group of American children between the ages of 9 and 15, according to a long-term study by ¿ìÈý¹ÙÍø-supported scientists. At ages 9 and 11, more than 90% of the children met recommended activity levels—at least 60 minutes of physical activities most days of the week. By age of 15, however, only 31% met the recommended level on weekdays, and only 17% on weekends.

Increased Allergen Levels in Homes Linked to Asthma

A little housecleaning may help to reduce asthma symptoms in people who have both asthma and allergies, suggests a study by ¿ìÈý¹ÙÍø scientists and their colleagues. A survey of more than 2,500 people showed that allergy-triggering substances, called allergens, were common in most homes. Households with asthmatic people were more likely to have higher levels of multiple allergens, including those from dog, cat, mouse and dust mite.